Monitor Closely (3)pentobarbital will minimize the extent or effect of diazepam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Powerful or moderate CYP3A4 inducers might boost fee of diazepam elimination; hence, efficacy of diazepam may be reduced.
Patients stabilized on corticosteroid therapy may possibly demand dosage adjustments if barbiturates are included to or withdrawn from their dosage routine due to induction of hepatic microsomal enzymes by barbiturates
pentobarbital will minimize the extent or result of tamoxifen by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
pentobarbital will reduce the extent or impact of estrogens esterified by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
pentobarbital will lower the level or effect of celecoxib by influencing hepatic enzyme CYP2C9/ten metabolism. Small/Significance Unidentified.
CYP3A4 inducers may enhance the development in the neurotoxic/nephrotoxic ifosfamide metabolite, chloroacetaldehyde. Closely watch sufferers taking ifosfamide with CYP3A4 inducers for website toxicities and consider dose adjustment.
pentobarbital will minimize the extent or effect of quinidine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
pentobarbital will lessen the level or impact of ambrisentan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unknown.
pentobarbital will reduce the extent or result of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
Contraindicated (one)pentobarbital will lessen the extent or result of lorlatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Check Closely (one)pentobarbital will reduce the level or outcome of glecaprevir/pibrentasvir by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital boosts toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. CYP3A4 inducers may possibly enhance the metabolism of ifosfamide to its active alkylating metabolites.
pentobarbital will reduce the level or influence of midostaurin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Powerful CYP3A4 inducers may possibly decrease midostaurin concentrations leading to minimized efficacy.
buprenorphine, long-acting injection and pentobarbital each improve sedation. Stay away from or Use Alternate Drug. Limit use to sufferers for whom different treatment method possibilities are insufficient